Kelly Clarkson has found her dream wedding dress

Los Angeles: Singer Kelly Clarkson, who is engaged to Brandon Blackstock, says she has found the wedding dress of her dreams."It is my personality in a dress. It`s sweetly damaged. A little rock and roll. A little tattered. Nothing like a princess thing!" aceshowbiz.com quoted Clarkson as saying.

Blackstock, a talent manager, proposed Clarkson at their Nashville home in December last year.

"Out of nowhere I just said, `Thanks for being an awesome guy`. I have never been loved properly by a man, and I was just like, `I thank you so much for that`," she said.

She didn`t know he would pop the question that day.

"Not a damn clue! I didn`t know life could be this happy," she added.

IANS

First Published: Monday, February 11, 2013, 07:39

Source: http://spicezee.feedsportal.com/c/33175/f/540066/s/286df7f0/l/0Lzeenews0Bindia0N0Centertainment0Carticles0Cstory1277460Bhtm/story01.htm

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Hot! Helen Mirren dyes her hair pink

By Us Weekly

Ian Gavan / Getty Images

Helen Mirren attends the EE British Academy Film Awards at The Royal Opera House on Feb. 10 in London.

Dame Helen Mirren is tickled pink with her new hair color! At the BAFTA Awards in London Sunday, Feb. 10, the Nicholas Oakwell Couture-clad actress debuted a shocking new shade on the red carpet.

PHOTOS: Celebrities with over-the-rainbow hair

"I just thought it would be fun to dye my hair pink," Mirren told reporters, according to the U.K.'s Daily Mail. "I mean, honestly, I was watching?"America's Next Top Model" and the season where there were the British girls. Well the British girl who won (Sophie?Sumner), she had pink hair, and I thought, 'That looks really pretty.' So I'm copying her, basically."

PHOTOS: Hot Hollywood hairstyles

Mirren, 67, was nominated in the Best Actress category for her work in "Hitchcock." She lost to Emmanuelle?Riva, the 85-year-old star of "Amour."

Source: http://todayentertainment.today.com/_news/2013/02/10/16919750-helen-mirren-dyes-her-hair-pink?lite

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'Jack The Giant Slayer' Secrets Revealed With Director Bryan Singer

Plus, watch an exclusive clip from the March 1 release.
By Amy Wilkinson, with reporting by Josh Horowitz

Eleanor Tomlinson in "Jack the Giant Slayer"
Photo: Warner Bros.

Source: http://www.mtv.com/news/articles/1701645/jack-the-giant-slayer-bryan-singer-secrets-revealed.jhtml

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New drug is first to help patients with recurrent low-grade ovarian cancer

Feb. 8, 2013 ? Low-grade serous ovarian cancer is less common and aggressive than the high-grade variety, yet exceptionally difficult to treat when frontline therapy fails.

"After surgery, with or without pre-surgical chemotherapy, when low-grade serous ovarian cancer persists or returns, chemotherapy and hormonal therapy are relatively ineffective," said David Gershenson, M.D., professor in The University of Texas MD Anderson Cancer Center Department of Gynecological Oncology and Reproductive Medicine.

Response rates for treatment are measured in single digits. Gershenson and colleagues have spent the greater part of 20 years characterizing the disease, which makes up 10 percent of ovarian cancer cases, and searching for new ways to treat it. Cancer recurs or persists in 80 to 85 percent of patients.

A phase II clinical trial by the National Cancer Institute's Gynecological Oncology Group provides the first evidence of a drug that shows a relatively high response rate for these patients.

Selumetinib halts growth or shrinks tumors

In the first-targeted therapy clinical trial for low-grade serous ovarian cancer, eight of 52 (15 percent) patients had a complete or objective partial response (tumor shrinkage) and 34 (65 percent) had no disease progression during the two-year course of the study. Study results appear in the February edition of The Lancet Oncology.

"These are remarkably encouraging results for what can ultimately be a devastating disease," said Gershenson, the paper's senior author.

These patients have a median overall survival of 80 months, about twice as long as those with high-grade disease, who are typically in their 60s when diagnosed and comprise 90 percent of ovarian cancer patients. The average age of women with low-grade cancer falls in the early 40s, Gershenson said, and it's not uncommon to see women in their 20s, 30s and 40s and the occasional teenager with the disease.

High-grade serous ovarian cancer is susceptible to chemotherapy upon relapse or recurrence.

Median overall survival not reached

Cancer-causing genetic mutations in BRAF and KRAS genes occur more frequently in low-grade ovarian cancer, so the researchers chose a drug that targets the molecular network that includes those genes.

Selumetinib inhibits MEK1/2, a critical molecule in what's known as the MAPK pathway, which includes BRAF and KRAS.

All 52 patients had received at least one previous therapy, with 30 having had three or more. Clinical trial results with selumetinib include:

* Median progression-free survival of 11 months and 34 patients (65 percent) went at least six months without their disease worsening.

* Two-year overall survival of 55 percent.

* Median overall survival had not been reached, because more than half of patients (61 percent) remained alive at the time of data cutoff for the study.

* No treatment-related deaths.

Side effects ranged from cardio and gastrointestinal toxicity to pain, fatigue, anemia and dermatological effects. Of the 52 patients, 22 had their doses reduced and 13 ultimately left the study due to side effects.

Researchers obtained tumor samples sufficient for DNA analysis from 34 patients. While 14 patients had KRAS mutations and two had BRAF mutations, there was no connection between having those mutations and whether the patients responded to selumetinib.

Gershenson said researchers will further explore the question of matching drug to mutation during a larger phase 2/3 clinical trial that he will lead with investigators from the NCI Gynecological Oncology Group and the United Kingdom. The study will enroll 250 patients and is likely to begin later this summer.

Phase 2 trials generally do not include a control or comparison group, but the team noted treatment results for 58 women not in the trial who were treated at MD Anderson with current options. Between them, these patients received 108 different chemotherapy regimens, which produced one complete and three partial responses for an overall response rate of 3.7 percent.

A step toward personalized therapy for ovarian cancer

In an accompanying commentary, Sven Mahner, M.D., and Jacobus Pfisterer, M.D., Ph.D., German oncologists who did not participate in the research, note that the study is a step toward individualized treatment for ovarian cancer that reflects important molecular differences between low-grade and high-grade disease.

The response rate and disease stabilization rate are "particularly promising in a setting of heavily pretreated recurrent disease."

"A strength of the study is mandatory reference pathology of recurrent disease to ensure exclusion of patients with progression to high-grade disease, who are likely to benefit from chemotherapy, and recurrent borderline ovarian tumors that have excellent prognosis with salvage surgery alone," Mahner and Pfisterer wrote.

Co-authors with Gershenson are first author John Farley, M.D., of Creighton University School of Medicine at St. Joseph's Hospital in Phoenix; William Brady, Ph.D., and Heather Lankes Ph.D., of Roswell Park Cancer Institute in Buffalo, N.Y.; Vinod Vathipadiekal, Ph.D., and Michael Birrer, M.D., of Massachusetts General Hospital, Boston; Robert Coleman, M.D., MD Anderson's Department of Gynecological Oncology; Mark Morgan, M.D., Fox Chase Cancer Center, Philadelphia; Robert Mannel, M.D., of University of Oklahoma Health Sciences Center, Oklahoma City; S. Diane Yamada, M.D., University of Chicago; David Mutch, M.D., Washington University School of Medicine, St. Louis, Mo., and William Rodgers, M.D., Lenox Hill Hospital, New York.

The clinical trial was sponsored by the Cancer Therapy Evaluation Program of the National Cancer Institute and funded by NCI grants (CA 27469 and CA 37517) to the Gynecological Oncology Group.

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Alt-week 2.9.13: Seismic invisibility, bacterial gold and really, really big prime numbers

Alt-week peels back the covers on some of the more curious sci-tech stories from the last seven days.

The the lure of gold, the unpredictable weather and the power of invisibility. What do these three things have in common? We'd argue their almost universal appeal to the human race. Science makes headway in all three of these areas in this edition. On top of that there's a really, incredibly, massive prime number. This is alt-week.

Filed under: Misc, Science, Alt

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/OSUyyu7XLJA/

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Hubble catches the moment the lights went out

Feb. 5, 2013 ? The further away you look, the further back in time you see. Astronomers use this fact to study the evolution of the Universe by looking at nearby and more distant galaxies and comparing their features. Hubble is particularly well suited for this type of work because of its extremely high resolution and its position above the blurring effects of Earth's atmosphere. This has allowed it to detect many of the most distant galaxies known, as well as making detailed images of faraway objects.

Comparing galaxies in the distant past with those around us today, astronomers have noticed that the nearby galaxies are far quieter and calmer than their distant brethren, seen earlier in their lives. Nearby galaxies (although not the Milky Way) are often large, elliptical galaxies with little or no ongoing star formation, and their stars tend to be elderly and red in color. These galaxies, in astronomers' language, are "red and dead."

This is not so for galaxies further away, which typically show more vigorous star birth.

The reason for this appears to be that as the Universe has aged, galaxies have often collided and merged together, and these events disrupt gas clouds within them. A merger will usually be a trigger for such intense star formation that the supply of gas is used up, and no more star formation occurs afterwards. The merged elliptical galaxy then creeps into old age, getting redder as its stars get older. This is expected to happen to the Milky Way when it merges with the nearby Andromeda Galaxy, some four billion years from now.

The galaxy in this image, catalogued as 2MASX J09442693+0429569, marks a transitional phase in this process as young, star-forming galaxies settle to become massive, red and dead galaxies.

The galaxy has tail-like features extending from it, typical of a galaxy that has recently undergone a merger. Studying the properties of the light from this galaxy, astronomers see no sign of ongoing star formation; in other words, the merger triggered an event which has used up all the gas. However, the observations suggest that star formation was strong until the very recent past, and has ceased only within the last billion years. This image therefore shows a snapshot of the moment star formation stopped forever in a galaxy.

A version of this image was entered into the Hidden Treasures image processing competition by contestant Nick Rose.

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Rouslan Toumaniantz, Tattoo Artist, Inked Name Across Girlfriend ...

Crazy Tattoos!!

Mexican Maria Jose Cristerna "The Vampire Woman" poses during the Expotattoo Venezuela 2013, in Caracas, on January 25, 2013. The event will be held in Caracas several days. (Juan Barreto, AFP / Getty Images)

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US Matt Gone gestures as he poses before the opening of the Expotattoo Venezuela 2013 in Caracas, on January 24, 2013. The event will be held in Caracas five more days. (Juan Barreto, AFP / Getty Images)

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British Isobel Varley displays her tattoos proudly at the Tattoo International Convention in Madrid 16 June 2001. Isabel Varley claims to be the most tattooed woman in the world. (Marc Alex, AFP / Getty Images)

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A tattooed panther is seen on the back of the head of a man during the 15th Annual Tattooing Convention in Manhattan in New York, May 19, 2012. (Miladen Antonov, AFP / Getty Images)

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A woman poses with her tattoos at the 19th International Tattoo Convention in the central German city of Frankfurt am Main on April 16, 2011. Tattoo artists from the whole world present the newest techniques, designs and colour creations over the weekend. (Boris Roessler, AFP / Getty Images)

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Jeremy Renfro shows off his "Buddha" tattoo at the "Inkin'' Lincoln Tattoo Jamboree" in Rosemont, Illinois, March 5, 2000. (Tim Boyle, Getty Images)

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Czech composer and painter Vladimir Franz attends a press conference on August 28, 2012 in Prague, Czech Republic. Franz announced he is planning to run for President in the Czech Republic's 2013 presidental election. (Martin Divisek, isifa / Getty Images)

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Mike Connor watches a performance at the annual New York Tattoo Convention on May 17, 2003 in New York City. The three-day event features dozens of booths with tattoo and piercing artists from around the world. Tattoos, once relegated to the fringe of American society, have become mainstream in recent years with everyone from mothers to high school students receiving the indelible designs on their skin. (Spencer Platt, Getty Images)

Crazy Tattoos!!

Retired teacher Geoff Ostling displays his tattooed skin at a portrait session at his home in Petersham on May 11, 2009 in Sydney, Australia. The 65-year old has pledged to donate his skin to the National Gallery in Canberra after his death. Ostling, who did not get his first tattoo until he was in his forties, is now covered in the artwork by artist eX de Merci from neck to ankle with the theme 'all the flowers of a Sydney garden'. (Lisa Maree Williams, Getty Images)

Crazy Tattoos!!

A man's back tattooed with cherubs and dancing girls. (General Photographic Agency / Getty Images)

Crazy Tattoos!!

Retired teacher Geoff Ostling displays his tattooed skin at a portrait session at his home in Petersham on May 11, 2009 in Sydney, Australia. The 65-year old has pledged to donate his skin to the National Gallery in Canberra after his death. Ostling, who did not get his first tattoo until he was in his forties, is now covered in the artwork by artist eX de Merci from neck to ankle with the theme 'all the flowers of a Sydney garden'. (Lisa Maree Williams, Getty Images)

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Tattooist Les Skuse at work on champion tattoo lady Pam Nash who has a large Japanese scene across her back April 1960. (John Pratt, Keystone Features / Getty Images)

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Tattooist Les Skuse at work on champion tattoo lady Pam Nash who has a large Japanese scene across her back April 1960. (John Pratt, Keystone Features / Getty Images)

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Mary Jose Cristerna, known as The Vampire Woman, from Mexico, poses for a portrait as she attends Venezuela Expo Tattoo 2012 in Caracas, Venezuela, Saturday Jan. 28, 2012. (Ariana Cubillos, AP)

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Married couple Ivor and Marianne Collier are covered in tattoos. Ivor's chest displays a work in progress version of Frans Hals' 'The Laughing Cavalier' circa 1970. (Keystone / Getty Images)

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Belgian Kimberley Vlaeminck, 18, gives a call at her home in Kortrijk on June 17, 2009. Vlaeminck said she had gone to the tattoo parlor in the western town of Courtrai and asked tattoo artist Rouslan Toumaniantz for three small stars on her face. Vlaeminck fell asleep and woke up sporting 56 black stars of various sizes on the left side of her face, from nose to ear and brow to chin. She said on June 16 she would sue the parlor which she said covered half her face with stars while she was asleep. (Peter Deconinck, AFP / Getty Images)

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Guinness World Record-holder Julia Gnuse, the "most tattooed woman" in the world, poses at BookExpo America at the Javits Center May 26, 2010 in New York City. Gnuse has tattoos covering 95 percent of her body and has used the same artist for every design. Guinness World Records 2011 edition will be available September 15. (Mario Tama, Getty Images)

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A 'Libere', one of hundreds of criminals living as free men in French colony of Guiana, after the dissolution of the penal colony at Devil's Island circa 1938. (De Long, Three Lions / Getty Images)

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This individual is sporting tattoos across their entire back circa 1970. (Hulton Archive / Getty Images)

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Tattooed music fan attends Day 1 of the Coachella Valley Music & Arts Festival 2011 held at the Empire Polo Club on April 15, 2011 in Indio, California. (Frazer Harrison, Getty Images)

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An Ainu woman from northern Japan with tattooed lips. The upper lip is slashed during childhood and ashes are rubbed in to leave a scar circa 1960. (Three Lions / Getty Images)

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A tattooist places some final touches to a man whose back consists almost entirely of tattoos circa 1955. (Juliette Lasserre, BIPs / Getty Images)

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A woman displays his tattoo during the third Sydney Tattoo and Body Art Expo on March 11, 2011. The expo, billed as the largest tattoo convention in the Southern Hemisphere, has over 320 tattoo artists including 110 internationals and over 60 retail vendors. (Greg Wood, AFP / Getty Images)

Crazy Tattoos!!

In spite of a ban since 1880, the ancient art of tattooing is still widely practiced amongst all classes in Japan circa 1958. (Keystone Features / Getty Images)

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Mexican tattoo artist and trained lawyer Maria Jose Cristerna, known as "Vampire Woman", attends the Fifth International Tattoo Convention in Bogota, Colombia, on June 4, 2011. (Eitan Abramovich, AFP / Getty Images)

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Larry Happ, 68, raises his arms to show his tattoos as he competes for the senior man largest tattoo during the Los Angeles Tattoo Convention held at the Los Angeles Marriott Airport Hotel 13 March. The convention runs through 15 March. (Mathilde de L'Ecotais, AFP / Getty Images)

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Tattoo artist Su-a-Sulu-Ape Freewind smiles at the Body Art Expo at the Cow Palace on August 27, 2005 in San Francisco, California. Several hundred thousand tattoo and body art enthusiasts are expected to attended the threr day event. (David Paul Morris, Getty Images)

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A heavily tattooed man poses for a portrait at the International Tattoo Convention at the Truman Brewary on October 6, 2007 in London, England. (Chris Jackson, Getty Images)

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Tattoo artist George Burchett working on a client's thigh. (General Photographic Agency / Getty Images)

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A man shows off his tattooed head on the opening day of the fifth London Tattoo Convention held at Tobacco Dock in the east end on September 25, 2009 in London, England. The three day, annual convention for all aspects of body art is one of the main events in the European tattoo circuit and was attended by 20,000 visitors last year. (Oli Scarff, Getty Images)

Crazy Tattoos!!

A woman displays her tattoos at the London International Tattoo Convention in east London, on September 26, 2009. Now in it's fifth year, the organizers attempted to break the record for "Most people in one place getting a new tattoo". (Leon Neal, AFP / Getty Images)

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An enthusiast displays his tattoo art and piercings at the London International Tattoo Convention in east London, on September 26, 2009. Now in it's fifth year, the organisers attempted to break the record for "Most people in one place getting a new tattoo". (Leon Neal, AFP / Getty Images)

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Volkswagen enthusiast, Chris Redford, shows his VW themed tattoos at the Final Fling VW Show on October 24, 2009 in Woolacombe, England. The small gathering of Volkswagen enthusiasts at a campsite in North Devon is generally seen as the last event of the year in the annual calendar of shows that celebrate all VW's including the iconic campervan. (Matt Cardy, Getty Images)

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A Maori warrior performs the "Powhiri", a ceremony to welcome visitors, at a giant rugby ball pavilion placed beside the Tokyo Tower on October 28, 2009. The New Zealand tourism office has built the giant pavilion to promote the 2011 Rugby World Cup in New Zealand, as well as New Zealand cultures. (Toshifumi Kitamura, AFP / Getty Images)

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Devotees of the Chinese Bank Neow Shrine take part in a procession through the streets to mark the annual Vegetarian Festival in southern Thailand's town of Phuket on October 13, 2010. The festival begins on the first evening of the ninth lunar month and lasts for nine days, with many religious devotees slashing themselves with swords, piercing their cheeks with sharp objects and committing other painful acts to purify themselves, taking on the sins of the community. (Nicolas Asfouri, AFP / Getty Images)

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A man with a completely tattooed face attends the Berlin Tattoo Convention at Tempelhof Airport on December 4, 2010 in Berlin, Germany. The Tattoo Convention takes place for the 20th time and the organizers expect over the three days over 15,000 visitors. There are artists from Japan, China, Taiwan, USA, Canada, Australia, New Zealand, Tahiti, Samoa, and from all European countries as guests, who come up with the latest technics, designs and color creations. (Carsten Koall, Getty Images)

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A man with a tattooed face attends the Berlin Tattoo Convention at Tempelhof Airport on December 4, 2010 in Berlin, Germany. The Tattoo Convention takes place for the 20th time and the organizers expect over the three days over 15,000 visitors. There are artists from Japan, China, Taiwan, USA, Canada, Australia, New Zealand, Tahiti, Samoa, and from all European countries as guests, who come up with the latest technics, designs and color creations. (Carsten Koall, Getty Images)

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Edyta from London poses for a photo showing her tattoos at the 18th International tattoo convention in the central German city of Frankfurt am Main on March 5, 2010. (Thomas Lohnes, AFP / Getty Images)

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Michelle "Bombshell" McGee tattoos at the Celebrity Wrestling 1 Press Conference at South Philly Bar and Grill on May 6, 2010 in Philadelphia, Pennsylvania. (Bobby Bank, Getty Images)

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A tatooed Dayak tribesman from West Kalimantan in Borneo island participate in a protest by members of indeginous tribe in Jakarta on January 12, 2011. The group denounces University of Indonesian sociologist for allegedly offending the Dayak tribe in a remark in December regarding sexual practices made while he was a witness in a pornography case trial of an Indonesian rock star. The sociologist research on several Indonesian tribes and Dayak people stating that sex without marriage is acceptable has caused negative perception of the Dayak people according to the protesters. (Romeo Gacad, AFP / Getty Images)

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People display their tattoos during the third Sydney Tattoo and Body Art Expo on March 11, 2011. The expo, billed as the largest tattoo convention in the Southern Hemisphere, has over 320 tattoo artists including 110 internationals and over 60 retail vendors. (Greg Wood, AFP / Getty Images)

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A picture taken on February 8, 2011 in Panmaung Village, in Myanmar's remote northwest, shows an ethnic minority Chin woman (R) bearing a facial tattoo. Ma Htwe recalled the day of agony she suffered, more than five decades ago, when her face was etched with the intricate tattoo that still lines her papery skin like a spider's web. With the practice ceasing two generations ago, Ma Htwe is now among a smattering of women left alive who bear the tattoos. When they die, the ancient tradition will die with them. (AFP / Getty Images)

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A man poses with his tattoos at the 19th International Tattoo Convention in the central German city of Frankfurt am Main on April 15, 2011. Tattoo artists from the whole world present the newest techniques, designs and colour creations over the weekend. (Boris Roessler, AFP / Getty Images)

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Steve Chambers adds to is collection of over 200 tattoos during the Ink For Heroes event on June 18, 2011 in Catterick, England. Ink For Heroes is a charity event to raise money and awareness of the soldiers that get injured during service, with all proceeds going to both 'Help The Heroes' and 'The British Legion'. Injured soldiers can also get tattooed for free during the event. (Bethany Clarke, Getty Images)

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British tattoo artist Karma Webb poses during the Nepal Tattoo Convention in Kathmandu on April 22, 2011. Some 57 tattoo artist from 10 different countries participated in the convention. (Prakash Mathema, AFP / Getty Images)

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A Cuban girl exposes her tattoo covering part of her right hemithorax, in Havana on July 22, 2011. (AFP / Getty Images)

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A tattoo artist shows off his Batman tatoo that he received at a stand at the 21st International Tattoo Convention Berlin on December 3, 2011 in Berlin, Germany. The annual tattoo trade fair runs from December 2-4, 2011. (Adam Berry, Getty Images)

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Canadian model Rick Genest aka Zombie boy presents a creation by French designer Thierry Mugler during the Men's fall-winter 2011-2012 ready-to-wear collection show on January 19, 2011 in Paris. (Francois Guillot, AFP / Getty Images)

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Iris (R) from Taiwan presents her tattoos at the international tattoo convention in Frankfurt/M., western Germany, on March 31, 2012. More than 650 tattooers from around 20 countries present their skills during the event running until April 1, 2012. (Boris Roessler, AFP / Getty Images)

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Bulgarian Genislav Naidenov shows his tattoos and piercings during an annual international tattoo contest in the Bulgarian capital Sofia, Sunday, May 4, 2008. Over the past few years tattoos have become popular among teenagers and there are many new tattoo studios around the country. (Petar Petrov, AP)

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A man displays his tattooed face at a tattoo convention in Beijing Saturday June 16, 2007. Hundreds attended the opening of the three-day China 2007 Tattoo Show in Beijing Saturday. The show, the third to be held in the Chinese capital, features tattoo competitions, stage performances and on-the-scene tattoos. (Greg Baker, AP)

Source: http://www.huffingtonpost.com/2013/02/04/rouslan-toumaniantz-girlfriend-face-tattoo_n_2617994.html

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