Thursday, January 31, 2013

Ray LaHood Exit Interview: We Are Behind On High Speed Rail

WASHINGTON -- Leaving what he called "the best job I've ever had," Transportation Secretary Ray LaHood took some parting shots at lawmakers, mainly his fellow Republicans, for lacking a vision on infrastructure proportional to current demands.

LaHood, who announced on Tuesday that he would be leaving his post in one month's time, made several bold predictions in an exit interview with The Huffington Post. Everyone, he argued, would own either a hybrid or a battery-powered vehicle by 2025, owing to new fuel efficiency standards; renewable energy would be a predominant fuel component for most forms of transportation; and infrastructure investment would become a second term policy priority for Congress along the lines of immigration reform.

"I hope that ... elections make a difference," said LaHood. "The president has spent four years talking about infrastructure. Every speech that he gives about putting America to work, he talks about infrastructure. And I hope that since the election, people come to realize that if you really want to get America back to work and put people to work, you have to make investments in infrastructure."

LaHood offered a few political observations as well, arguing that members of Congress needed to understand the risks they were taking by underfunding the country's infrastructure future.

"For the first time since people have been looking at infrastructure, America is behind," LaHood said. "We are behind other countries because other countries are making the investments that we used to make. We got a two-year [highway] bill because they could only find $109 billion. We need to do better and we need to make sure that America does not fall further behind when it comes to infrastructure."

Beyond their stinginess, however, LaHood criticized lawmakers -- his fellow Republicans in particular -- for lacking a comprehensive vision for improvements to infrastructure.

LaHood's views on the matter were shaped, in part, by his attempts in spring 2011 to convince Florida Gov. Rick Scott (R) to accept federal funds to build high-speed rail lines in his state. Scott, in a nod to the fiscal hawks in his party, declined to take the funds, arguing that the project would have required too heavy an investment from his own budget.

"My thought was there is only one person in Florida who doesn't want this money," LaHood said of the episode. "He is a governor without a vision when it comes to transportation."

Scott's office did not return a request for comment.

In the end, the Obama administration allocated $12 billion for high-speed rail nationwide -? a historic investment in its own right. But when pressed, LaHood says that more needs to be spent.

"Look, we are behind on high-speed rail," he said. "But because of the president's vision and because of the work of those of us here at DOT, we have come a long way ... As long as President Obama is in the White House, whoever sits in this chair will have high-speed rail as one of their top priorities."

The political battles around high-speed rail, and those standoffs with Scott in particular, will undoubtedly be part of LaHood's legacy. But for transportation junkies, many policies pursued and political battles waged were more consequential. Though his tenure witnessed notable controversies over transportation safety -- the most recent involving Boeing's 787 fleet -- LaHood put a major focus on many elements of safe travel, such as pushing for pilots and bus drivers to get sufficient rest. Most notably, he was the first transportation secretary to emphasize the dangers of distracted driving, texting behind the wheel in particular.

"I think that four years ago no one even knew what distracting driving was," he said. "We've gotten people's attention with that. And I think it has made a difference and saved some lives and saved some injuries."

LaHood also became a major proponent of an environmentally friendly urban transportation agenda. He spoke out against elevated highways and in favor of "livable neighborhoods," used federal money to help build trolley lines and became a champion of bike lines and cyclist's rights. (To demonstrate his commitment, he once donned a helmet and rode a bike to work himself.)

He said, in a prior interview with The Huffington Post, that he didn't know if his defense of bikers made him a hipster. But as he gets set to leave the Department of Transportation, he argued that the Obama agenda would ultimately prove to be the trendsetter.

"As members of Congress understand that the people are way, way ahead of them on this -- they are way ahead of most members, certainly on the Republican side, when it comes to high speed rail, or walking and biking paths, or livable, sustainable communities, green energy, the people are so far ahead of the politicians on this -- eventually it will catch up with them," he said.

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Source: http://www.huffingtonpost.com/2013/01/29/ray-lahood-interview-high-speed-rail_n_2576995.html

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Golf: Olympic legend Phelps signs golf equipment deal

Last updated at 3:54 pm

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Insiders Buy Stocks In National Beverage, And Sell Costco | Stocks ...

In a victory for common sense, the trading behavior of company executives, directors, and large shareholders in the stocks of firms they're registered "insiders" at have been proven profitable to monitor by both academic studies and (more importantly) the experience of your fellow professional investors.

Below are lists of the top 10 mainly open-market insider purchases and sales filed at the Securities and Exchange Commission Tuesday, January 29, 2013 as ranked by dollar value.

Please note, however, that these are factual lists, not buy and sell recommendations. Dollar value is only one metric to assess the importance of an insider transaction, and, frankly, often not even the most important metric that determines if an insider transaction is significant.

In insider purchases, George Bracken, Principal Financial Officer and Vice President of Finance at National Beverage (NASDAQ:FIZZ), bought $20,000,000 worth of the company, which is the fifth largest soft drink company in the US. The health care dedicated investment firm OrbiMed Advisors bought $1,142,481 worth of stock in Anthera Pharmaceuticals (NASDAQ:ANTH), which is focused on developing and commercializing products to treat diseases related with inflammation. Twin Haven Special Opportunities Fund, a beneficial owner of Hawaii's dominant local telephone company, Hawaiian Telecom?(NASDAQ:HCOM), bought $389,707 worth of company stock. ?

In sales, Dwight Schar, a Director of NVR, Inc.?(NYSE:NVR), sold $5,365,343 worth of stock. The company is engaged in both home building and mortgage banking. At the real estate investment trust?Corporate Office Properties Trust (NYSE:OFC), which specializes in office development, Director Clay Hamlin III sold $2,469,816 worth of company stock. Chairman of Google?(NASDAQ:GOOG), Eric Schmidt, sold $2,224,362 worth of company stock. Douglas Schutt, Executive Vice President and Chief Operating Officer of Merchandising for Costco Wholesale (NASDAQ:COST), sold $2,059,258 of company stock.

At InsiderInsights.com, we find new investment ideas just about every day using these and more intricate insider screens to determine where we should focus our subsequent fundamental and technical analysis. And while stocks don't (or shouldn't) move up or down based on insider activity alone, insiders tend to be good indicators of when real stock-moving events like earnings surprises, corporate actions, and new products may be in the offing.

Insider Purchases
#: Filer Name Insider Titles Company Name Ticker Trans
Type
Dollar Value

1

VP,FO

JB*

$20,000,000

2

DIR

B

$1,142,481

3

BO

B

$389,707

4

CEO,DIR,BO

JB*

$325,000

5

DIR

B

$293,000

6

CB,CEO,TT

B

$179,716

7

CB,CEO,FO

B

$117,849

8

DIR

JB*

$100,008

9

DIR

B

$94,001

10

CB,CEO,TT

B

$70,159

Source: InsiderInsights.com | Key to Insider Title and Trans Type Codes


Insider Sales
#: Filer Name Insider Titles Company Name Ticker Trans
Type
Dollar Value

1

DIR

S

$5,365,343

2

DIR

AS

$2,469,816

3

CB,DIR

AS

$2,224,362

4

VP

S

$2,059,258

5

BO

S

$1,685,247

6

VP,CFO

AS

$1,284,971

7

DIR

S

$1,215,000

8

BO

S

$1,185,063

9

VP,CFO

AS

$1,113,083

10

VP,DIR

S

$1,112,655

Source: InsiderInsights.com | Key to Insider Title and Trans Type Codes

Editor's note: Jonathan Moreland is the founder of Insider Insights and author of "Profit From Legal Insider Trading."

No positions in stocks mentioned.

Source: http://www.minyanville.com/trading-and-investing/stocks/articles/A-Purchase-at-National-Beverage-and/1/30/2013/id/47753

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Chimp see, chimp learn: First evidence for chimps improving tool use techniques by watching others

Jan. 30, 2013 ? Chimps can learn more efficient ways to use a tool by watching what others do, according to research published Jan. 30 in the open access journal PLOS ONE by Shinya Yamamoto and colleagues from Kyoto University and Kent University, UK. Their study presents the first experimental evidence that chimps, like humans, can watch and learn a group member's invention of a better technique.

Chimps in the study were provided juice-boxes with a small hole and straws to drink with. One group of chimps used the straws like dipsticks, dipping and removing them to suck on the end, while the other group learned to suck through the straw directly. Learning both techniques required the same cognitive and motor skills, but chimps that drank through the straw got considerably more juice in a shorter amount of time. When the first group of chimps watched either a human or a chimp demonstrate the more efficient 'straw-sucking' technique, all of them switched to using this instead.

The study concludes, "When chimpanzees are dissatisfied with their own technique, they may socially learn an improved technique by closely observing a proficient demonstrator."

According to the authors, their results provide insights into the cognitive basis for the evolution of culture in chimpanzees, and suggest ways that culture could evolve in non-human animals.

The present study was financially supported by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology in Japan (MEXT: 20002001, 24000001, and MEXT special grant ''Human Evolution'' to T. Matsuzawa) and from Japan Society for the promotion of Science (JSPS: 18-3451, 21-9340, 22800034 and 40585767 to S. Yamamoto).

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Story Source:

The above story is reprinted from materials provided by Public Library of Science.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Shinya Yamamoto, Tatyana Humle, Masayuki Tanaka. Basis for Cumulative Cultural Evolution in Chimpanzees: Social Learning of a More Efficient Tool-Use Technique. PLoS ONE, 2013; 8 (1): e55768 DOI: 10.1371/journal.pone.0055768

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/YPEZGgp5i-o/130130184158.htm

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PHOTOS: Justin Bieber Wears His Underwear to the Pool!

Justin Bieber hangs by the pool in his briefs! Check out more pics of Hollywood's tightest twosomes

Source: http://www.ivillage.com/star-snapshots-celebrity-photo-gallery-2012/1-b-450006?dst=iv%3AiVillage%3Astar-snapshots-celebrity-photo-gallery-2012-450006

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APNewsBreak: EPA moves to ban some rodent poisons

WASHINGTON (AP) ? The Environmental Protection Agency is moving to ban the sale of a dozen rat and mouse poisons sold under the popular D-Con brand in an effort to protect children and pets.

The agency said Wednesday it hopes to reduce the thousands of accidental exposures that occur every year from rodent-control products. Children and pets are at risk for exposure because the products typically are placed on floors.

The agency had targeted a handful of companies two years ago, saying they needed to develop new products that are safer for children, pets and wildlife. All but Reckitt Benckiser Inc., manufacturer of D-Con, did so.

The company will have at least 30 days to request a hearing before an administrative law judge. If no hearing is requested, the ban will take effect.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-01-30-Rodent%20Poisons/id-daa051d16e334f389823571a9742a6d2

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Wednesday, January 30, 2013

Rats, like humans, return to drinking once punishment is removed

Jan. 30, 2013 ? Once heavy drinking impairs function, a variety of punishment-related threats may motivate people to stop drinking: spouses may threaten divorce, employers may threaten job loss, and courts threaten drunk drivers with losing their driver's license or incarceration. In the face of these threats, many alcohol abusers refrain from drinking, but relapse is very common when the threats of punishment fade, particularly when exposed to alcohol-associated environments (contexts).

A new study by researchers at the National Institute on Drug Abuse suggests that rats may behave in the same way. This is important because a significant amount of addiction research is performed in animals, using models of addiction, before it is translated to work in humans.

"The better our animal models fit human alcoholism, the more our animal research will help us to understand the complexity of the human disorder and to develop new treatments," commented Dr. John Krystal, Editor of Biological Psychiatry.

Currently, the most commonly employed techniques to achieve alcohol abstinence in animal work are forced abstinence and/or extinction training, where a lever press that used to consistently deliver alcohol no longer does so. These models of relapse are limited because they do not incorporate behaviors that mimic a human's desire to avoid negative consequences of drinking.

To address this divergence between animal models and the human condition, Nathan Marchant and colleagues developed a rat relapse model in which voluntary alcohol intake is suppressed by punishment in an environment that is different from the original alcohol intake environment.

They showed that when rats were re-exposed to the original alcohol self-administration environment, after suppression of alcohol intake in a different environment by punishment, they immediately relapsed to alcohol seeking.

"A potential clinical implication of this preclinical finding is that abstinence induced by introducing adverse consequences on alcohol intake in inpatient treatment clinics would have a limited effect on subsequent alcohol use in the home environment after completion of treatment," commented Marchant.

As with nearly all such scientific work, the findings themselves are interesting, but they also lead to many more questions. What is the potential influence of medication or other manipulations on this model? Would the model hold up when other drugs of abuse or even food were studied? Does the passage of time have any effect on this model? More work will be undertaken to answer these and other related questions.

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Story Source:

The above story is reprinted from materials provided by Elsevier, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Nathan J. Marchant, Thi N. Khuc, Charles L. Pickens, Antonello Bonci, Yavin Shaham. Context-Induced Relapse to Alcohol Seeking After Punishment in a Rat Model. Biological Psychiatry, 2013; 73 (3): 256 DOI: 10.1016/j.biopsych.2012.07.007

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/jCfCS-bdWfI/130130082449.htm

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White House praises Senate immigration plan (The Arizona Republic)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/280078679?client_source=feed&format=rss

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Udacity, San Jose State University offer online classes for credit

The SJSU campus.

(Credit: Wikimedia Commons) So you've graduated from high school and been accepted at a four-year college. But when you arrive on campus you find out that you can't pass college entry-level courses, so it's back to remedial classes. That's the fate of half of all freshman at San Jose State University, according to Provost Ellen Junn. Add to those woes decreases in funding for higher education across California, higher tuition fees, and greater competition for college admission.

Those are just some of the reasons the university has partnered with Silicon Valley startup Udacity to offer San Jose State Plus, online courses for academic credit. These types of classes are called MOOCs (massive open online courses), and San Jose State administrators say this new program marks the first time a MOOC is being offered purely online for credit.

Udacity began offering MOOCs in early 2012. Wondering how massive a "massive" open online course is? Udacity currently has 250,000 people enrolled in one of its computer science offerings.

When students sign up for an Udacity MOOC, they watch short interactive videos online and take quizzes to make sure they've grasped the material before the next concept is introduced. "There's actually no lecturing in what we do, or very minimal lecturing," said Udacity co-founder Sebastian Thrun. "It's really all about student exercise. You learn by making your brain go crazy. You don't learn by just listening." In other words, no more dozing off during class.

Can a Silicon Valley startup solve state university woes?

To start, San Jose State Plus is offering three classes: entry-level math, college algebra, and elementary statistics. These are classes that are often over-enrolled and create bottlenecks because students must pass them to graduate. The courses are limited to veterans and students in high school at community colleges or at San Jose State. The fee for each class is $150.

That's another benefit of MOOCs -- the cost per student is extremely low. San Jose State professor Ron Rogers, co-instructor for the elementary statistics class, said that the cost of the textbook alone for the same class on campus is $150. The MOOC version of the class requires no textbook.

Students who've enrolled in MOOCs say they like being able to set their own pace for the courses, without concern for the rest of the class. They can move ahead when they're ready and replay videos when the lesson isn't quite sinking in.

This isn't to say that MOOCs are flawless. Dropout rates are high. When a course is offered for free, it's easy to sign up on a whim. When Udacity launched, I signed up for Computer Science 101 only to find myself canceling dentist appointments and skipping gym workouts to try to hand in homework assignments on time. I made it halfway through the eight-week course before I gave in and dropped out. Not a proud moment, but it was either that or poor dental hygiene. To help, San Jose State Plus is adding mentors to the program. Their job? To prod, push, encourage, and provide help for students as needed.

San Jose State Plus came together in record time. It began with a phone call back in June when Calif. Gov. Jerry Brown rang up Thrun and said that California was in a crisis and the state needed his help. Skip ahead seven months, and January 30 marks the debut of the first San Jose State-branded MOOCs.

Thrun isn't done yet, though. He loves the idea of MOOCs helping students get a four-year degree in four years (instead of the average six years currently needed by many) and helping them save tuition fees along the way. But he also has his eye on some other under-served students: "We want to help lots of high school students. We want to level the playing field and even allow inner city students or disadvantaged students to go out into college with as much credit as they can and be as successful as they can be."

Source: http://news.cnet.com/8301-1023_3-57566552-93/udacity-san-jose-state-university-offer-online-classes-for-credit/

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Earnings signs stall Britain's FTSE at 4-1/2 year highs

* FTSE 100 opens flat

* Imperial Tobacco weighs after pessmismistic trading update

* Petrofac falls after Saipem's update sees shares fail to

open

* Equity still favoured by investors as majority of stocks

gain

LONDON, Jan 30 (Reuters) - Britain's blue-chip index stalled

around 4-1/2 year highs in early trade on Wednesday, with

negative earnings guidance issued by several companies weighing

on an already technically 'overbought' index.

An almost 5 percent dive for Imperial Tobacco alone

knocked 4 points off the FTSE 100 and taking it briefly

into negative territory, after the firm said that it expects

first-half operating profit to fall due to increased competition

from the black market.

Petrofac led the list of fallers in percentage

terms, losing 7 percent, with traders citing a negative

readacross from Italian firm Saipem, whose shares

failed to make a price in opening trade after slashing guidance

for 2013.

That all ate into an optimistic run on the market since the

start of this year, but by 0935 GMT, the index was still 10

points higher at 6,349.08.

"People have a big appetite for equities right now, but I'm

still fairly cautious," said Nick Xanders, head of European

equity strategy at brokerage BTIG.

"Imperial is a expensive defensive that didn't meet

expectations, and the oil sector is being dragged down by

collateral damage from the whole Saipem situation.

"So you've got a lot of people who are well and truly

involved in the market who are getting a bit twitchy."

The FTSE 100 has rallied for five consecutive days, gaining

2.6 percent overall and pushing its 14 day relative strength

index (RSI) above 90 for the first time since May 1997. A level

over 70 indicates that an asset is 'overbought'.

"With bonds in clear retreat it would appear that investors

are moving into equities as the asset class of choice and most

sentiment indicators are now extremely bullish," Bill McNamara,

technical analyst at Charles Stanley, said in a note.

"The next upside target is 6,376 or so and that might still

be hit in the near term, but the argument in favour of an

imminent corrective phase is becoming irresistible."

While the big movers of the day were all fallers, the

majority of stocks managed gains - a sign that the underlying

bullishness has yet to run out of steam.

WPP was the only blue chip to gain over 2 percent,

following an upgrade from Jefferies to 'Buy' from 'Hold'.

"The shift to a lower risk, bolt-on strategy frees up cash

for higher dividends and lowers integration risks," analysts at

Jefferies say in a note.

"We see the risk-reward attractively balanced."

(Editing by Patrick Graham)

Source: http://news.yahoo.com/earnings-signs-stall-britains-ftse-4-1-2-095048219--business.html

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WADA calls UCI 'deceitful' in doping probe

LONDON (AP) ? The World Anti-Doping Agency called the UCI "deceitful" Tuesday for shutting down its independent doping panel and said it won't participate in an amnesty commission set up by the cycling governing body.

WADA said the UCI has "again chosen to ignore its responsibility to the sport" by disbanding the panel looking into claims that cycling leaders helped cover up Lance Armstrong's suspicious doping tests and accepted $125,000 from him in donations.

Instead, the UCI announced Monday plans to set up a separate amnesty-style "truth and reconciliation commission" that it claimed was supported by WADA President John Fahey.

"This is not only wrong in content and process, but again deceitful," WADA said in a statement. "The fact is that WADA was awaiting a reply to the correspondence when the UCI release was delivered.

"WADA has not and will not consider partaking in any venture with UCI while this unilateral and arrogant attitude continues."

The anti-doping agency added that it will not "pay for or contribute to any collaborative effort with UCI into investigating UCI's long-standing problems with doping in its sport and its alleged complicity."

Accusations against the UCI emerged in the U.S. Anti-Doping Agency report that detailed doping and led to Armstrong being stripped of his seven Tour de France titles. Armstrong recently confessed to doping after years of denials.

In justifying the reason to disband the independent panel, the UCI cited WADA's refusal to cooperate with the inquiry.

But WADA on Tuesday said it would not participate because of the "inadequacies of the terms of reference and the timelines." It also didn't want the UCI to scrutinize or edit the findings before they were released.

WADA said it hopes the UCI's independent commission will still meet as previously planned on Thursday, despite being disbanded. The three-person body said Tuesday the UCI never provided the cooperation ? promised by UCI President Pat McQuaid ? to allow it to function.

"This failure to cooperate makes our task impossible," the commission, which was chaired by British judge Philip Otton, said in a statement. "Therefore, the proposed hearing on (Jan. 31) will not take place."

Source: http://news.yahoo.com/wada-calls-uci-deceitful-doping-probe-155901435--spt.html

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Tuesday, January 29, 2013

Nicholas Hoult Warm Bodies Interview

"Warm Bodies" is the first zombie movie told from the point of view of the zombie himself -- and, as played by Nicholas Hoult, he's surprisingly charming. Here, Hoult (Hank McCoy, aka Beast, in "X-Men: First Class") stars as "R.," the Romeo-esque undead lead character who can't remember his full name. However, he does remember (barely) what it was like to be human when he meets Julie (Teresa Palmer) and decides to protect her rather than eat her brains. What follows is a very unlikely romance that changes the status quo for both zombies and humans.

Hoult spoke to Moviefone about his zombie makeover, fake brains and the hardest part about playing someone who's supposed to be undead.

What was your first reaction when someone approached you to star in a zombie romantic comedy?
No one really said much about the concept of it. I'd heard some good things and I saw that it was adapted by Jonathan Levine, and he was going to direct it. I was a fan of his already, so I thought it was probably going to be something interesting. And then I started reading it and just really enjoyed it. It was funny and sweet and the character was just something that I really wanted to play.

What was your inspiration for your zombie walk?
We kind of did a bit of zombie schooling. It was more a feeling of just being really tired.
Stumbling around a little bit and just a slight lack of coordination. We watched a lot of zombie films in the build-up just to kind of get an idea of what had been done before. We didn't want to get too over-the-top and ridiculous. We wanted something more subtle.

What's your favorite zombie movie?
I do really like "Shaun of the Dead" and "Zombieland." But "28 Days Later" is great as well.

Do you think a zombie romance is a tough sell for audiences?
At first, you have some internal voiceover and you realize that before he was undead, but this is quite a witty guy with a dry sense of humor that, hopefully, has a charm to him. So I think it's more about people to like that side of his personality than how he looks.

What was the toughest part of playing a zombie?
Not laughing, actually, is really difficult, particularly doing scenes with Rob Corddry.
We'd literally do scenes where there was nothing scripted, it was just me and him grunting and kind of having a conversation. One of us would do a weird grunt and then we'd both start cracking up.

You get probably the first zombie makeover in movie history.
Yeah, that was also a difficult scene not to laugh throughout. Slapping the makeup on me, yeah.

Do you think horror purists will enjoy it?
That's a tricky one because people get quite possessive of the zombie characters and feel as though they shouldn't think and all they should do is hunt and that's it. Once people see it and see the humor in it and let go of that a little bit, I think they can enjoy it. I think they'll be entertained.

What were the "brains" you're seen eating?
They were a kind of wet, peachy sponge thing with grapefruit and stuff. It was an odd taste. Nothing that I'd recommend.

What's going on with the "X-Men: First Class" sequel?
I think we start shooting later on this year. I haven't read anything yet but I've heard it's a really cool script. They're still working on it a little bit, but I think it's going to be very exciting.

Beast has gone through a major transformation: Does that mean we won't be seeing you onscreen anymore in your non-mutated form?
Well, wait and see on that.

What do you hope happens in the sequel?
I'm dying to find out more. I know they've got some cool stuff planned. It was a character I really enjoyed playing. I'm just looking forward to being with those actors again and with Bryan Singer directing as well. I did a film with recently him, "Jack the Giant Slayer," so it'll be nice to work with him again.

Do you still have people telling you how much they loved you in "About a Boy?"
Sometimes, yeah. Earlier on today, there was a nice lady I met who was a really big fan of it. It's great that people still hold that film dear in their hearts. I'm very proud of it. The Weitz brothers are some of the nicest people to work with and great directors. I was fortunate to work with them and learn from them.

So now you've played a mutant and a zombie... what's next?
Next, I suppose, I'm in "Mad Max." I'm playing a warrior driver character. It was a lot of fun and a very cool movie to be a part of. Just the vehicles they built and the story and the action. George Miller, the director, is a top guy so I had a lot of fun working for him.

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Source: http://www.rottentomatoes.com/m/1926745/news/1926745/

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India cuts rates after 9-month wait, RBI stays cautious

MUMBAI (Reuters) - India's central bank lowered its key policy rate as expected for the first time in nine months to support an economy set for its slowest growth in a decade, but signaled there was less room for aggressive cuts in future due to concerns over inflation.

The Reserve Bank of India cut the policy repo rate by 25 basis points to 7.75 percent, in line with a Reuters poll earlier this month.

The RBI unexpectedly also reduced the cash reserve ratio (CRR), the share of deposits banks must keep with the central bank by 25 bps to 4.00 percent, which will infuse an additional 180 billion rupees into the banking system.

India's headline inflation rate moderated to a three-year low of 7.18 percent in December, and the central bank said there was likelihood that inflation would remain rangebound around current levels heading into 2013/14 fiscal year starting April.

"This provides space, albeit limited, for monetary policy to give greater emphasis to growth risks," the central bank said in its quarterly monetary policy review.

Bond and stock markets were largely unmoved as dealers had already priced in a quarter percentage point rate cut. The 10-year bond yield was flat at around 7.87 percent. India's main NSE index <.nsei> was also flat, with the bank sub-index <.nsebank> up 0.2 percent, paring initial stronger gains.

The Indian rupee strengthened to 53.79 to the dollar from around 53.84 before the decision.

"RBI has not abandoned its cautious stance, stressing on the 'calibrated and limited' nature of rate support (from) hereon," said Radhika Rao, economist, Forecast Pte in Singapore.

"The scale of rate cuts is closely tied to the government's sustained efforts to correct the twin imbalances and moderating inflation trajectory."

The central bank however reiterated its concerns over a bloated fiscal and current account deficits (CAD) adding that its pro-growth stance will be conditioned by the management of the risks posed by them.

"Financing the CAD with increasingly risky and volatile flows increases the economy's vulnerability to sudden shifts in risk appetite and liquidity preference, potentially threatening macroeconomic and exchange rate stability," the RBI said.

Since a 50 basis point cut in April, the central bank had kept interest rates on hold as inflation stayed stubbornly high, ignoring repeated calls from the government for a cut.

Having grown at near-double-digit pace before the Lehman Brothers crisis, the economy has suffered a rapid deceleration.

The RBI cut its GDP growth forecast for Asia's third-largest economy to 5.5 percent for the current fiscal year, from 5.8 percent previously, and lowered its projection for headline inflation in March to 6.8 percent from 7.5 percent earlier.

(Additional reporting by Mumbai treasury team; Editing by Simon Cameron-Moore)

Source: http://news.yahoo.com/indias-central-bank-cuts-policy-rate-25-bps-054334509--business.html

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Student Recreation | InnerVU | Vanderbilt University

Vanderbilt Recreation Center ? Twenty Third Anniversary

Intramural Registration
Registrations can be completed at the Office of Campus Recreation from 9 am ? 5 pm Mon. ? Fri. Each house?s vice president will be responsible for assisting the Office of Campus Recreation in promoting and registering teams for both the Commons sporting events and intramural sports. For more info call 3-8186.

Men?s & Women?s Programs Entry Date?Start Date
Badminton?????????????????????????????????????????? Jan. 28 ? Feb 1 ? ? ? ? ? Feb. 9
Bowling ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? Feb 4 ? 8 ? ? ? ? ? ? ? ? ? ?Feb 16
Soccer ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?Feb 25 ? Mar 1 ? ? ? ? ? ? Mar 17

Co-Rec Programs Entry Date?Start Date
Soccer ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? Feb 25 ? Mar 1 ? ? ? ? ? ? Mar 17
Ultimate Frisbee????????????????????????????????? Mar 11 ? 15???????????????? Mar 24

For a complete calendar of activities for the 2013 Spring semester, ?please check out our website at?http://www.vanderbilt.edu/studentrec/intramurals/calendar/.

Smoothie King is now open in the Vanderbilt Student Recreation Center.

Work on the Natchez Field has begun. This renovation will create two softball fields. The spring 2013 softball season will be played at this location.

The expansion on the southwest corner of the Rec is well underway. This area will host more fitness room space and
multi-purpose rooms.

Foundations are nearing completion. Steel for the project will be arriving in the next few weeks.

To see aerial shots provided by Aerial Innovations of TN and to see our progress, go tohttp://www.vanderbilt.edu/studentrec/facilities-improvement-for-you/.

Now hiring?Swim Instructors?and?Lifeguards?for Spring / Summer 2013.

Swim Instructors: Swim Instructors are needed for both private and group lessons. Previous experience required.

Lifeguards: Lifeguards are needed for recreational swimming, lap swimming and OCR programs. Duties include opening and closing pool, enforcing pool rules and swimmer safety. Each lifeguard must possess a current lifeguard and CPR-professional rescuer certifications.

Pay is $8.00 per hour

Please contact:?kit.wilson@vanderbilt.edu


CPR/First Aid Classes @ The Rec

Sunday, February 3rd, 2013, 4 ? 9 pm
Sunday, February 17th, 2013, 4 ? 9 pm
Sunday, March 10th 2013, 4 ? 9 pm

Sign up in the Office of Campus Recreation.

Registration

Be sure to register as soon as possible. Class size is limited to 15 participants based on first come, first served and will fill up quickly!

Cost: $120 (Payment is due at the time of registration. Please make checks payable to Vanderbilt University.)

To register, stop by the Office of Campus Recreation during office hours, Monday-Friday 9am-5pm. For more information, email?kate.vanlandingham@vanderbilt.edu or call 343-8186.?No Phone Reservations.

Classes are held in Classroom A & B of the Student Recreation Center.

Group Fitness Classes This Week

For Aerobics & Yoga Class Descriptions, please got to our website athttp://www.vanderbilt.edu/studentrec/fitness/group-fitness/.

Mondays

11:30 ? 12:30 pm?YOGA with Polly
4:00 ? 5:00 pm?HIP HOP CARDIO with Kimberly
5:00 ? 6:00 pm?ZUMBA with Carney
6:15 ? 6:30 pm?HARD@AA with Alyson
6:30 ? 7:00 pm?HARDCORE with Alyson
7:00 ? 8:00 pm?SPIN with Johnny

Tuesdays

6:00 ? 6:45 am?SPIN EXPRESS with Lindey
10:00 ? 11:00 am?CARDIO BLAST with Jennifer
1:00 ? 1:30 pm?CARDIO EXPRESS with Kimberly
3:00 ? 4:00 pm?HARDBODY with Alyson
4:00 ? 5:00 pm?BOOT CAMP with Johnny (meets @ Front Desk)
4:30 ? 5:30 pm?BEGINNER YOGA with Stephen
5:30 ? 6:30?YOGA with Stephen

Wednesdays

6:00 ? 7:00 am??PILATES with Stefanie
7:00 ? 8:00 am?30/20/10 with Kimberly
11:30 ? 12:30 pm ?YOGA with Polly
4:30 ? 5:30 pm??ZUMBA with Carney
5:30 ? 6:30 pm??MEDITATION CLASS with Natalie (meets in classroom A)
5:30 ? 6:30 pm??KICKBOXING with Madeleine
6:30 ? 7:00 pm?HARDCORE with Alyson
7:00 ? 8:00 pm??SPIN with Johnny

Thursday

6:00 ? 6:45 am?SPIN EXPRESS with Lindey
7:00 ? 8:00 am?YOGA with Polly
4:00 ? 5:00 pm?BOOT CAMP with Johnny (meets @ Front Desk)
5:00 ? 5:30 pm?ZUMBA EXPRESS with Hannah
5:30 ? 6:30 pm ?YOGA with Stephen
6:00 ? 7:00 pm?AQUA BOOT CAMP with Kathryn (meets at pool)

Friday

10:00 ? 11:00 am?CARDIO BLAST with Jennifer
3:30 ? 4:30 pm ZUMBA with Carney
4:30 ? 5:30?SPIN with Alyson
5:30 ? 6:30 pm ??BODY BURN with Madeleine

Saturday

10:15 ? 11:15 am ? YOGA with Polly

Sunday

12:30 ? 1:30 pm ?SPIN with Johnny
2:00 ? 3:00 pm?STEP N CORE with Kathryn
3:00 ? 4:00 pm?TURBOKICK with Kathryn
4:00 ? 4:30 pm?AWESOME ABS with Kathryn
4:30 ? 5:30 pm?ZUMBA with Hannah
5:30 ? 6:30 pm?CARDIO CIRCUIT with Carney
6:30 ? 7:30 pm?30/20/10 with Kimberly

Recreation Facility Hours:
Mon.- Thu ?????? 5:30 am ? 11 pm
Fri ?????????????????? 5:30 am ? 12 am
Sat?????????????????? 9 am ? 10 pm
Sun????????????????? 12 pm? ? 11 pm
Visit our website at?http://www.vanderbilt.edu/studentrec/

?



Source: http://www.vanderbilt.edu/innervu/news/student-recreation-27

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Neuroscientists pinpoint location of fear memory in amygdala

Jan. 27, 2013 ? A rustle of undergrowth in the outback: it's a sound that might make an animal or person stop sharply and be still, in the anticipation of a predator. That "freezing" is part of the fear response, a reaction to a stimulus in the environment and part of the brain's determination of whether to be afraid of it.

A neuroscience group at Cold Spring Harbor Laboratory (CSHL) led by Assistant Professor Bo Li Ph.D., together with collaborator Professor Z. Josh Huang Ph.D., have just released the results of a new study that examines the how fear responses are learned, controlled, and memorized. They show that a particular class of neurons in a subdivision of the amygdala plays an active role in these processes.

Locating fear memory in the amygdala

Previous research had indicated that structures inside the amygdalae, a pair of almond-shaped formations that sit deep within the brain and are known to be involved in emotion and reward-based behavior, may be part of the circuit that controls fear learning and memory. In particular, a region called the central amygdala, or CeA, was thought to be a passive relay for the signals relayed within this circuit.

Li's lab became interested when they observed that neurons in a region of the central amygdala called the lateral subdivision, or CeL, "lit up" in a particular strain of mice while studying this circuit.

"Neuroscientists believed that changes in the strength of the connections onto neurons in the central amygdala must occur for fear memory to be encoded," Li says, "but nobody had been able to actually show this."

This led the team to further probe into the role of these neurons in fear responses and furthermore to ask the question: If the central amygdala stores fear memory, how is that memory trace read out and translated into fear responses?

To examine the behavior of mice undergoing a fear test the team first trained them to respond in a Pavlovian manner to an auditory cue. The mice began to "freeze," a very common fear response, whenever they heard one of the sounds they had been trained to fear.

To study the particular neurons involved, and to understand them in relation to the fear-inducing auditory cue, the CSHL team used a variety of methods. One of these involved delivering a gene that encodes for a light-sensitive protein into the particular neurons Li's group wanted to look at.

By implanting a very thin fiber-optic cable directly into the area containing the photosensitive neurons, the team was able to shine colored laser light with pinpoint accuracy onto the cells, and in this manner activate them. This is a technique known as optogenetics. Any changes in the behavior of the mice in response to the laser were then monitored.

A subset of neurons in the central amygdala controls fear expression

The ability to probe genetically defined groups of neurons was vital because there are two sets of neurons important in fear-learning and memory processes. The difference between them, the team learned, was in their release of message-carrying neurotransmitters into the spaces called synapses between neurons. In one subset of neurons, neurotransmitter release was enhanced; in another it was diminished. If measurements had been taken across the total cell population in the central amygdala, neurotransmitter levels from these two distinct sets of neurons would have been averaged out, and thus would not have been detected.

Li's group found that fear conditioning induced experience-dependent changes in the release of neurotransmitters in excitatory synapses that connect with inhibitory neurons -- neurons that suppress the activity of other neurons -- in the central amygdala. These changes in the strength of neuronal connections are known as synaptic plasticity.

Particularly important in this process, the team discovered, were somatostatin-positive (SOM+) neurons. Somatostatin is a hormone that affects neurotransmitter release. Li and colleagues found that fear-memory formation was impaired when they prevent the activation of SOM+ neurons.

SOM+ neurons are necessary for recall of fear memories, the team also found. Indeed, the activity of these neurons alone proved sufficient to drive fear responses. Thus, instead of being a passive relay for the signals driving fear learning and responses in mice, the team's work demonstrates that the central amygdala is an active component, and is driven by input from the lateral amygdala, to which it is connected.

"We find that the fear memory in the central amygdala can modify the circuit in a way that translates into action -- or what we call the fear response," explains Li.

In the future Li's group will try to obtain a better understanding of how these processes may be altered in post-traumatic stress disorder (PTSD) and other disorders involving abnormal fear learning. One important goal is to develop pharmacological interventions for such disorders.

Li says more research is needed, but is hopeful that with the discovery of specific cellular markers and techniques such as optogenetics, a breakthrough can be made.

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Story Source:

The above story is reprinted from materials provided by Cold Spring Harbor Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Haohong Li, Mario A Penzo, Hiroki Taniguchi, Charles D Kopec, Z Josh Huang, Bo Li. Experience-dependent modification of a central amygdala fear circuit. Nature Neuroscience, 2013; DOI: 10.1038/nn.3322

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/lxzF37HaE7w/130128104739.htm

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Monday, January 28, 2013

Patients' own skin cells are transformed into heart cells to create 'disease in a dish'

Patients' own skin cells are transformed into heart cells to create 'disease in a dish'

Monday, January 28, 2013

Most patients with an inherited heart condition known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) don't know they have a problem until they're in their early 20s. The lack of symptoms at younger ages makes it very difficult for researchers to study how ARVD/C evolves or to develop treatments. A new stem cell-based technology created by 2012 Nobel Prize winner Shinya Yamanaka, M.D., Ph.D., helps solve this problem. With this technology, researchers can generate heart muscle cells from a patient's own skin cells. However, these newly made heart cells are mostly immature. That raises questions about whether or not they can be used to mimic a disease that occurs in adulthood. In a paper published January 27 in Nature, researchers at Sanford-Burnham Medical Research Institute and Johns Hopkins University unveil the first maturation-based "disease in a dish" model for ARVD/C. The model was created using Yamanaka's technology and a new method to mimic maturity by making the cells' metabolism more like that in adult hearts. For that reason, this model is likely more relevant to human ARVD/C than other models and therefore better suited for studying the disease and testing new treatments.

"It's tough to demonstrate that a disease-in-a-dish model is clinically relevant for an adult-onset disease. But we made a key finding here?we can recapitulate the defects in this disease only when we induce adult-like metabolism. This is an important breakthrough considering that ARVD/C symptoms usually don't arise until young adulthood. Yet the stem cells we're working with are embryonic in nature," said Huei-Sheng Vincent Chen, M.D., Ph.D., associate professor at Sanford-Burnham and senior author of the study.

To establish this model, Chen teamed up with expert ARVD/C cardiologists Daniel Judge, M.D., Joseph Marine, M.D., and Hugh Calkins, M.D., at Johns Hopkins University. Johns Hopkins is home to one of the largest ARVD/C patient registries in the world.

"There is currently no treatment to prevent progression of ARVD/C, a rare disorder that preferentially affects athletes. With this new model, we hope we are now on a path to develop better therapies for this life-threatening disease," said Judge, associate professor and medical director of the Center for Inherited Heart Disease at the Johns Hopkins University School of Medicine.

Disease in a dish

To recreate a person's own unique ARVD/C in the lab, the team first obtained skin samples from ARVD/C patients with certain mutations believed to be involved in the disease. Next they performed Yamanaka's technique: adding a few molecules that dial back the developmental clock on these adult skin cells, producing embryonic-like induced pluripotent stem cells (iPSCs). The researchers then coaxed the iPSCs into producing an unlimited supply of patient-specific heart muscle cells. These heart cells were largely embryonic in nature, but carried along the original patient's genetic mutations.

However, for nearly a year, no matter what they tried, the team couldn't get their ARVD/C heart muscle cells to show any signs of the disease. Without actual signs of adult-onset ARVD/C, these young, patient-specific heart muscle cells were no use for studying the disease or testing new therapeutic drugs.

Speeding up time

Eventually, the team experienced the big "aha!" moment they'd been looking for. They discovered that metabolic maturity is the key to inducing signs of ARVD/C, an adult disease, in their embryonic-like cells. Human fetal heart muscle cells use glucose (sugar) as their primary source of energy. In contrast, adult heart muscle cells prefer using fat for energy production. So Chen's team applied several cocktails to trigger this shift to adult metabolism in their model.

After more trial and error, they discovered that metabolic malfunction is at the core of ARVD/C disease. Moreover, Chen's team tracked down the final piece of puzzle to make patient-specific heart muscle cells behave like sick ARVD/C hearts: the abnormal over-activation of a protein called PPAR?. Scientists previously attributed ARVD/C to a problem in weakened connections between heart muscle cells, which occur only in half of the ARVD/C patients. With the newly established model, they not only replicated this adult-onset disease in a dish, but also presented new potential drug targets for treating ARVD/C.

What's next?

Chen's team was recently awarded a new grant from the California Institute for Regenerative Medicine to create additional iPSC-based ARVD/C models. With more ARVD/C models, they will determine whether or not all (or at least most) patients develop the disease via the same metabolic defects discovered in this current study.

Together with the Johns Hopkins team, Chen also hopes to conduct preclinical studies to find a new therapy for this deadly heart condition.

###

Sanford-Burnham Medical Research Institute: http://www.burnham-inst.org

Thanks to Sanford-Burnham Medical Research Institute for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126483/Patients__own_skin_cells_are_transformed_into_heart_cells__to_create__disease_in_a_dish_

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S&P 500 slips after rally, but Apple lifts Nasdaq

NEW YORK (Reuters) - The S&P 500 edged lower on Monday as a four-week rally stalled, while a rebound in Apple shares helped buoy the Nasdaq.

Caterpillar shares helped cap losses in the Dow industrials even as the company posted a 55 percent drop in quarterly profit due to a charge connected with accounting fraud at a Chinese subsidiary and weak demand among its dealers. Caterpillar's shares, down 2.2 percent in the past three sessions, rose 1.5 percent Monday to $96.97.

The S&P 500 is coming off a streak of eight sessions of gains, the longest in eight years. On Friday, the major U.S. stock indexes closed a fourth straight week of gains with the S&P 500 ending the session above 1,500 for the first time in more than five years.

The rally has left the market vulnerable to a short-term pullback of up to 3 percent in the S&P 500 as bullish sentiment continues to rise, according to Richard Ross, Auerbach Grayson's global technical strategist.

"Still," Ross said, "we have a lot of momentum and nice seasonality, and technicals support the long-term bull market."

Data on Monday pointed to growing economic momentum as companies sensed improved consumer demand.

Thomson Reuters data showed that of the 150 companies in the S&P 500 that have reported earnings so far, 67.3 percent have beaten analysts' expectations, which is a higher proportion than over the past four quarters and above the average since 1994.

The Dow Jones industrial average <.dji> fell 9.02 points or 0.06 percent, to 13,886.96, the S&P 500 <.spx> lost 1.5 points or 0.1 percent, to 1,501.46 and the Nasdaq Composite <.ixic> added 8.46 points or 0.27 percent, to 3,158.17.

Bargain hunters lifted Apple after the tech giant's stock dropped 14.4 percent in the previous two sessions. With Apple's stock up 2.4 percent at $450.29, the iPad and iPhone maker regained the title as the largest U.S. company by market capitalization as Exxon Mobil fell 0.9 percent to $90.94 and slipped back to second place.

"I think there is more downside in Apple if you did get a broad market pullback," Auerbach Grayson's Ross said.

"I'd be patient unless you're a trader. It might not be the most attractive entry point."

U.S. durable goods orders jumped 4.6 percent in December, a pace that far outstripped expectations for a rise of 1.8 percent. Pending home sales unexpectedly dropped 4.3 percent. Analysts were looking for an increase of 0.3 percent.

Equities have also gained support from a recent agreement in Washington to extend the government's borrowing power. On Monday, Fitch Ratings said that agreement removed the near-term risk to the country's 'AAA' rating.

Hess Corp shares shot up 5.3 percent to $62.02 after the company said it would exit its refining business, freeing up to $1 billion of capital. Separately, hedge fund Elliott Associates is looking for approval to buy about $800 million more in Hess stock.

Keryx Biopharmaceuticals Inc said a late-stage trial of its experimental kidney disease drug met the main study goal, and its shares soared 67 percent to $5.75.

(Editing by Jan Paschal and Nick Zieminski)

Source: http://news.yahoo.com/stock-index-futures-signal-slight-gains-104646069--finance.html

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